| Date | Opponents | Time | At | HRs |
| May. 1 | at Tampa Bay | L 3-4 | Moehler(L,3-3)-Runyan-Anderson | |
| May. 2 | at Tampa Bay | W 8-2 | Thompson(W,4-2)-Nitcowski-Kida | Easley(5) |
| May. 3 | at Tampa Bay | L 6-14 | Blair(L,0-4)-Rojas-Runyan-Kida-Brocail | Jefferies(3) |
| May. 4 | Anaheim | W 3-1 | Mlicki-Brocail(W,1-0)-Jones(S,4) | Palmer(4) |
| May. 5 | Anaheim | L 1-4 | Weaver(L,3-2)-Anderson-Nitcowski-Kida | |
| May. 6 | Anaheim | W 4-2 | Florie(W,1-0)-Nitcowski-N.Cruz-Runyan-Brocail-Jones(S,5) | Kapler(2) |
| May. 7 | Baltimore | L 4-9 | Thompson(L,4-3)-N.Cruz-Kida-Anderson | Kapler(3),Haselman(2) |
| May. 9 | Baltimore | W 7-6 | Blair(W,1-4)-Kida-Nitcowski-Brocail-Jones(S,6) | Palmer(5),Jefferies(4) |
| May. 10 | Baltimore | L 0-5 | Mlicki(L,1-2)-Anderson-Nitcowski-N.Cruz | |
| May. 11 | Oakland | L 2-6 | Weaver(L,3-3)-Florie-Nitcowski-Anderson-Kida | |
| May. 12 | Oakland | L 1-2 | Thompson(L,4-4)-Kida-Nitcowski-Brocail | |
| May. 14 | Cleveland | L 2-4 | Moehler-Nitcowski-Brocail(L,1-1)-Kida | Kapker(4) |
| May. 15 | Cleveland | L 7-12 | Mlicki(L,1-3)-Florie-Anderson-Jones | Macias(1),Catalanotto(2) |
| May. 16 | Cleveland | W 9-3 | Weaver(W,4-3)-Kida(S,1) | To Clark(4),Higginson(4,5) |
| May. 18 | at Toronto | L 5-7 | Thompson(L,4-5)-Florie-Nitcowski-Anderson | |
| May. 19 | at Toronto | W 7-3 | Moehler(W,4-3)-Kida-Nitcowski-Brocail | Encarnacion(4),Higginson(6),Palmer(6) |
| May. 20 | at Toronto | L 0-7 | Mlicki(L,1-4)-Kida-Jones | |
| May. 21 | at Cleveland | W 9-6 | Blair-Florie-Nitcowski(W,1-1)-Anderson-Brunson-Jones(S,7) | Catalanotto(3,4) |
| May. 22 | at Cleveland | W 6-2 | Weaver(W,5-3)-Anderson-Nitcowski-Brocail | Palmer(7) |
| May. 23 | at Cleveland | L 4-7 | Thompson-Kida-Brunson-Brocail-Jones(L,0-1) | |
| May. 24 | Toronto | L 6-12 | Moehler(L,4-4)-Anderson-Brunson-Florie | |
| May. 25 | Toronto | L 3-5 | Mlicki(l,1-5)-Kida-Nitcowski-Brocail | Palmer(8),Easley(6) |
| May. 26 | Toronto | L 5-9 | Blair(L,1-5)-Florie-Nitcowski-Anderson-Jones | Higginson(7),Palmer(9) |
| May. 27 | Chi.White Sox | W 10-5 | Weaver(W,6-3)-Kida-Brocail | Ausmus(4) |
| May. 28 | Chi.White Sox | L 1-9 | Thompson(L,4-6)-Florie-Anderson-Brunson | K Garcia(3) |
| May. 29 | Chi.White Sox | L 1-7 | Moehler(L,4-5)-Brunson-Brocail-Jones | |
| May. 30 | Chi.White Sox | W 3-2 | Mlicki(W,2-5)-Brocail-Jones(S,8) | Palmer(10),Kapler(5) |
| May. 31 | at Boston | L 7-8 | Florie-Nitcowski-Anderson(L,1-1)-Kida | Palmer(11),Higginson(8),Kapler(6) |
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