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| Date | Opponents | Time/Result | Pitchers | HRs |
| May. 1 | at Texas | W 6-3 (10) | Sparks-Murray-Anderson-Patterson(W,2-0)-Jones(S,6) | Cruz(2) |
| May. 2 | at Texas | W 8-4 | Holt(W,3-2)-Anderson(S,1) | |
| May. 3 | at Texas | W 9-4 | Mlicki(W,2-2)-Nitcowski | Cedeno(1);Encarnacion(3);Palmer(3) |
| May. 4 | at Anaheim | L 5-7 | Perisho-Santos-Murray(L,0-1)-Anderson | |
| May. 5 | at Anaheim | W 11-2 | Weaver(W,3-4)-Nitcowski-Jones | Palmer(4);Clark(5);Easley(1) |
| May. 6 | at Anaheim | L 2-3 (10) | Sparks-Patterson(L,2-1) | |
| May. 8 | Texas | W 5-4 | Holt-Miller-Santos-Anderson-Nitcowski-Jones(W,1-2) | |
| May. 9 | Texas | W 3-2 | Mlicki(W,3-2)-Nitcowski-Patterson-Jones(S,7) | |
| May.10 | Texas | W 6-5 | Weaver-Anderson-Nitcowski-Patterson(W,3-2)-Jones(S,8) | Clark(6) |
| May.11 | Anaheim | W 7-6 (11) | Sparks-Murray-Nitcowski-Patterson-Jones(W,2-2) | Higginson(5)-Easley(2) |
| May.12 | Anaheim | W 4-1 | Santos-Nitcowski-Anderson(W,2-0) | |
| May.13 | Anaheim | L 2-14 | Holt(L,3-3)-Murray-Miller-Sparks | |
| May.15 | at Baltimore | L 3-11 | Mlicki(L,3-3)-Murray-Miller | |
| May.16 | at Baltimore | L 2-3 | Weaver(L,3-5) | Encarnacion(4);Higginson(6) |
| May.17 | at Baltimore | W 7-5 | Sparks(W,2-2)-Anderson-Patterson-Jones(S,9) | Encarnacion(5);Fick(4) |
| May.18 | at Tampa Bay | W 18-2 | Santos(W,1-0)-Borkowski-Murray-Nitcowski | Encarnacion(6) |
| May.19 | at Tampa Bay | W 10-5 | Holt(W,4-3)-Anderson-Nitcowski-Patterson(S,1) | Palmer(5);Easley(3,4) |
| May.20 | at Tampa Bay | L 2-10 | Mlicki(L,3-4)-Borcowski-Nitcowski-Jones | |
| May.21 | at Cleveland | W 3-0 | Weaver(W,4-5)-Nitcowski-Jones(S,10) | Fick(5);Palmer(6) |
| May.22 | at Cleveland | L 3-4 (10) | Sparks-Anderson-Nitcowski-Patterson-Jones-Borcowski(L,0-1) | Palmer(7) |
| May.24 | at Cleveland | L 5-8 | Santos(L,1-1)-Borcowski-Murray | |
| May.25 | Chi.White Sox | L 4-8 | Holt-Murray-Anderson-Nitcowski-Patterson-Jones(L,2-3)-Tolar | Fick(6) |
| May.26 | Chi.White Sox | L 0-8 | Mlicki(L,3-5)-Tolar-Borcowski | |
| May.27 | Chi.White Sox | L 2-3 (11) | Weaver-Nitcowski-Patterson(L,3-2)-Murray-Anderson | |
| May.28 | Cleveland | W 12-6 | Sparks(W,3-2)-Nitcowski-Anderson-Jones | Magee(1);Palmer(8) |
| May.29 | Cleveland | L 4-6 | Santos-Murray(L,0-2)-Borcowski | Easley(5) |
| May.30 | Cleveland | L 4-8 | Holt(L,4-4)-Tolar-Nitcowski | |
| May.31 | at Chi.White Sox | PPD by Rain | ||