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| Date | Opponents | Time/Result | Pitchers | HRs |
| Apr. 3 | Minnesota | L 2-3 | Weaver(L,0-1) | |
| Apr. 5 | Minnesota | L 5-9 (10) | Moehler-Jones(L,0-1)-Nitcowski-Perisho-Patterson | Higginson(1) |
| Apr. 6 | at Chi.White Sox | W 10-9 (10) | Mlicki-Nitcowski-Anderson-Perisho-Patterson(W,1-0)-Jones(S,1) | Clark(1);Cruz(1) |
| Apr. 7 | at Chi.White Sox | W 5-3 | Holt(W,1-0)-Jones(S,2) | Palmer(1) |
| Apr. 8 | at Chi.White Sox | W 5-3 | Weaver(W,1-1)-Patterson-Anderson-Jones(S,3) | |
| Apr. 9 | at Minnesota | L 5-11 | Sparks(L,0-1)-Santos | Mcmillon(1);Fick(1) |
| Apr.10 | at Minnesota | L 2-8 | Perisho(L,0-1)-Murray-Anderson | Higginson(2) |
| Apr.11 | at Minnesota | L 1-12 | Mlicki(L,0-1)-Nitcowski-Anderson-Santos | |
| Apr.12 | Cleveland | L 3-5 | Holt(L,1-1)-Murray-Nitcowski-Jones | |
| Apr.13 | Cleveland | L 8-9 | Weaver(L,1-2)-Patterson-Nitcowski-Anderson | Macias(1) |
| Apr.14 | Cleveland | W 1-0 | Sparks(W,1-1) | |
| Apr.15 | Cleveland | PPD,Rain | ||
| Apr.17 | Chi.White Sox | W 7-4 | Mlicki-Nitcowski-Anderson(W,1-0)-Jones(S,4) | Clark(2);Macias(2) |
| Apr.18 | Chi.White Sox | L 4-6 | Holt(L,1-2)-Santos-Patterson | Encarnacion(1);Higginson(3) |
| Apr.19 | Chi.White Sox | L 1-3 | Weaver(L,1-3)-Anderson-Murray | |
| Apr.20 | at Cleveland | L 4-5 | Sparks-Murray-Anderson-Nitcowski(L,0-1)-Jones | Clark(3);Encarnacion(2) |
| Apr.21 | at Cleveland | L 4-5 (11) | Perisho-Anderson-Nitcowski-Patterson-Jones(L,0-2) | Fick(2) |
| Apr.22 | at Cleveland | L 3-11 | Mlicki(L,0-2)-Murray-Holt | Higginson(4) |
| Apr.24 | Baltimore | L 3-8 | Weaver(L,1-4)-Santos-Perisho | Fick(3) |
| Apr.25 | Baltimore | L 4-6 | Sparks-Anderson-Jones | Clark(4) |
| Apr.26 | Baltimore | W 8-2 | Holt(W,2-2) | Macias(3) |
| Apr.27 | Tampa Bay | W 4-2 | Mlicki(W,1-2)-Patterson-Jones(S,5) | Macias(4) |
| Apr.28 | Tampa Bay | L 3-7 | Perisho(L,0-2)-Santos-Murray-Anderson-Nitcowski | |
| Apr.29 | Tampa Bay | W 6-1 | Weaver(W,2-4)-Nitcowski-Patterson | Palmer(2) |