| 日付 | 対戦相手 | スコア | 投手 | 本塁打 |
| Apr. 1 | at Minnesota | L 5-7 | Brocail-Sager-Miceli (L, 0-1)-M Myers | Nieves(1) |
| Apr. 2 | at Minnesota | L 6-7 | Thompson-Lira-M Myers-Miceli-Cummings-T Jones(L,0-1) | Higginson(1);Walbeck(1) |
| Apr. 3 | at Minnesota | L 6-10 | Blair(L,0-1)-Hernandez-Cummings-Sager-M Myers-Lira | To Clark(1) |
| Apr. 4 | at Chi White sox | W 8-7 | Moehler-M Myers-Lira-Miceli-T Jones(W,1-1)-Sager(S,1) | |
| Apr. 5 | at Chi White sox | W 15-12 | Olivares-FHernandez-Blair(W,1-1)-Sager-T Jones(S,1) | To Clark2(2,3);Easley(1);Higginson(2) |
| Apr. 6 | at Chi White sox | L 3-5 | Brocail(L,0-1)-Miceli | Nieves(2) |
| Apr. 7 | Minnesota | W 10-4 | Thompson(W,1-0)-Sager-T Jones | B Johnson(1) |
| Apr. 9 | Minnesota | W 10-5 | Moehler-Lira-Cummings(W,1-0)-Miceli-T Jones | Higginson(3) |
| Apr. 10 | Minnesota | L 3-7 | Blair(L,1-2)-Bautista-Cummings-Miceli-M Myers | Trammell(1) |
| Apr. 11 | at Chi White sox | W 5-4 | Olivares(W,1-0)-Sager-M Myers-T Jones | |
| Apr. 12 | at Chi White sox | Postponed by Rain |
| Apr. 13 | at Chi White sox | L 8-11 | Brocail-Bautista-T Jones-M Myers-Lira(L,0-1)-Cummings | Fryman(1) |
| Apr. 13 | at Chi White sox | W 4-2 | Thompson-Sager(W,1-0) | Fryman(2) |
| Apr. 14 | at Milwaukee | L 0-7 | Moehler-Miceli-M Myers | |
| Apr. 15 | at Milwaukee | W 3-1 | Blair(W,2-2)-M Myers-T Jones(S,3) | To Clark(4) |
| Apr. 16 | Seattle | L 3-7 | Olivares-Cummings-Sager(L,1-1)-M Myers-Miceli | To Clark(5);Nieves(3) |
| Apr. 17 | Seattle | L 6-8 | Lira-Bautista(L,0-1)-Cummings | Trammell(2);To Clark(6) |
| Apr. 18 | Oakland | L 5-9 | Brocail-Sager-M Myers(L,0-1)-T Jones-Miceli | |
| Apr. 19 | Oakland | L 1-7 | Thompson(L,1-1)-Bautista-T Jones | |
| Apr. 20 | Oakland | W 9-2 | Moehler(W,1-1)-Miceli | To Clark(7),Brian L Hunter(1);Easley(2) |
| Apr. 21 | at Texas | W 7-6 | Blair-Cummings-M Myers-Sager(W,2-1)-T Jones-Miceli(S,1) | Fryman(3) |
| Apr. 23 | at Texas | L 1-2 | Olivares-Brocail(L,0-2)-M Myers-Miceli | |
| Apr. 24 | at Texas | L 2-4 | Thompson(L,1-2)-Sager-M Myers-T Jones | Fryman(4) |
| Apr. 25 | at Anaheim | L 3-8 | Lira(L,0-2)-Cummings-Miceli | Trammell(3) |
| Apr. 26 | at Anaheim | W 2-0 | Moehler(W,2-1) | Fryman(5);Easley(3) |
| Apr. 27 | at Anaheim | L 5-6 | Blair-Bautista-Cummings-T Jones-M Myers(L,0-2) | Trammell(4);Brian L Hunter(2);Fryman(6);To Clark(8) |
| Apr. 29 | Milwaukee | L 1-2 | Olivares(L,1-1)-Cummings-Miceli-Brocail | |
| Apr. 30 | Milwaukee | W 8-4 | Thompson(W,2-2)-Sager-T Jones | |
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