| 日付 | 対戦相手 | 試合開始 | 投手 | 本塁打 |
| Apr. 2 | at Tampa Bay | L 5-9 | Weaver-Miller-Acevedo(L,0-1)-Patterson | |
| Apr. 3 | at Tampa Bay | L 1-2 | Sparks-Paniagua-Patterson-Farnsworth(L,0-1) | Fick(1) |
| Apr. 4 | at Tampa Bay | L 2-9 | Lima(L,0-1)-Pearson-Miller-Farnsworth-Anderson | Cruz(1);Rivera(1) |
| Apr. 5 | Cleveland | L 1-10 | Redman(L,0-1)-Perisho | |
| Apr. 6 | Cleveland | L 3-5 | Cornejo(L,0-1)-Acevedo-Anderson | Higginson(1) |
| Apr. 7 | Cleveland | L 1-5 | Weaver(L,0-1)-Paniagua-Pearson | |
| Apr. 8 | Chicago | PPD,Rain |
| Apr. 9 | Chicago | L 2-8 | Sparks(L,0-1)-Farnsworth-Pearson | |
| Apr.10 | Chicago | L 5-7 | Lima(L,0-2)-Acevedo-Perisho-Paniagua-Anderson | Higginson(2);Young(1);Simon(1) |
| Apr.12 | at Minnesota | L 2-4 | Redman(L,0-2)-Paniagua | |
| Apr.13 | at Minnesota | L 3-7 | Weaver(L,0-2)-Acevedo-Perisho-Pearson | |
| Apr.14 | at Minnesota | L 7-13 | Sparks-Paniagua-Anderson(L,0-1)-Acevedo | Paquette(1,2);Simon(2) |
| Apr.16 | Tampa Bay | W 9-3 | Lima(W,1-2)-Walker-Paniagua-Acevedo | Simon(3) |
| Apr.17 | Tampa Bay | W 7-6 | Redman-Acevedo-Anderson(W,1-1) | Magee(1);Simon(4) |
| Apr.18 | Tampa Bay | L 4-6 | Weaver(L,0-3)-Perisho-Paniagua-Farnsworth | |
| Apr.19 | at Chicago | W 8-2 | Sparks(W,1-1)-Paniagua | Salazar(1) |
| Apr.20 | at Chicago | L 5-12 | Cornejo(L,0-2)-Perisho-Farnsworth | |
| Apr.21 | at Chicago | L 8-11 | Lima-Acevedo-Walker-Paniagua(L,0-1)-Anderson | Higginson(3) |
| Apr.22 | at Kansas City | L 0-6 | Redman(L,0-3)-Santana | |
| Apr.23 | at Kansas City | W 3-0 | Weaver(W,1-3) | Simon(5) |
| Apr.24 | at Kansas City | L 2-8 | Sparks(L,1-2)-Acevedo-Walker-Anderson | |
| Apr.26 | Minnesota | W 3-2 | Greisinger-Acevedo-Anderson(W,2-1) | Higginson(4);Fick(2) |
| Apr.27 | Minnesota | W 5-1 | Cornejo(W,1-2) | Simon(6) |
| Apr.28 | Minnesota | W 5-4 | Redman-Paniagua-Acevedo-Walker-Santana(W,1-0) | Inge(1);Simon(7) |
| Apr.29 | Kansas City | L 0-4 | Weaver(L,1-4)-Santana-Walker | |
| Apr.30 | Kansas City | W 9-3 | Sparks(W,2-2) | |
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