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| 日付 | 対戦相手 | 試合開始 | 投手 | 本塁打 |
| Apr. 3 | at Oakland | W 7-4 | Nomo(W,1-0)-Brocail-Jones(S,1) | Palmer(1) |
| Apr. 4 | at Oakland | L 1-3 | Nitcowski(L,0-1)-Patterson-Anderson-Poole | |
| Apr. 5 | at Oakland | L 2-8 | Moehler(L,0-1)-Anderson-Blair-Poole-Patterson | |
| Apr. 7 | at Baltimore | L 10-14 | Mlicki(L,0-1)-Johnson-Poole-Anderson | Magee(1);Clark(1);Palmer(2);Ausmus(1);Encarnacion(1) |
| Apr. 8 | at Baltimore | L 1-2 (10) | Nomo-Brocail(L,0-1) | |
| Apr. 9 | at Baltimore | L 6-11 | Nitcowski-Blair-Patterson-Jones | Encarnacion(2);Palmer(3) |
| Apr. 11 | Seattle | W 5-2 | Moehler(W,1-1)-Patterson-Brocail-Jones(S,2) | |
| Apr. 12 | Seattle | L 0-4 | Mlicki(L,0-2)-Anderson-Poole-Johnson | |
| Apr. 13 | Seattle | W 2-0 | Nomo-Poole-Patterson-Brocail(W,1-1)-Jones(S,3) | |
| Apr. 14 | Tampa Bay | W 10-5 | Nitcowski(W,1-2)-Patterson-Blair | Clark(2);Gonzalez(1) |
| Apr. 15 | Tampa Bay | L 0-7 | Weaver(L,0-1)-Anderson-Johnson | |
| Apr. 16 | Tampa Bay | L 6-7 | Moehler-Brocail-Jones(L,0-1) | Palmer(4) |
| Apr. 18 | Boston | L 0-7 | Mlicki(L,0-3)-Patterson-Blair-Poole | |
| Apr. 19 | Boston | L 0-10 | Nomo(L,1-1)-Anderson-Poole-Blair-Johnson | |
| Apr. 20 | Boston | Postponed by rain | ||
| Apr. 21 | at Chi White Sox | L 2-7 | Nitcowski(L,1-3)-Anderson-Patterson-Blair | Encarnacion(3) |
| Apr. 22 | at Chi White Sox | L 6-14 | Weaver(L,0-2)-Poole-Patterson-Brocail-Jones-Blair | Magee(2) |
| Apr. 23 | at Chi White Sox | L 4-9 | Borcowski(L,0-1)-Johnson-Poole-Anderson | Palmer(5);Gonzalez(2);Higginson(1,2) |
| Apr. 24 | at Anaheim | L 4-10 | Mlicki(L,0-4)-Blair-Brocail | Gonzalez(3) |
| Apr. 25 | at Anaheim | W 4-2 | Nomo-Poole(W,1-0)-Brocail-Jones(S,4) | Easley(1) |
| Apr. 26 | at Anaheim | L 1-6 | Nitcowski(L,1-4)-Patterson-Poole-Anderson | D.Cruz(1) |
| Apr. 28 | Chi.White Sox | L 2-3 | Weaver(L,0-3) | Encarnacion(4) |
| Apr. 29 | Chi.White Sox | L 1-2 | Mlicki(L,0-5)-Poole-Anderson | |
| Apr. 30 | Chi.White Sox | W 4-3 (12) | Nomo-Jones-Patterson-Poole-Anderson(W,1-0) | |