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| Date | Opponent | Result | Pitchers | HRs |
| May. 2 | at Cleveland | Postponed by Rain | ||
| May. 3 | at Cleveland | L 6-7 | Moehler-Cummings-Miceli-M Myers-Brocail(L,0-3) | To Clark(9) |
| May. 4 | at Cleveland | W 2-0 | Blair(W,3-2)-Cummings-Brocail(S,1) | |
| May. 5 | at Toronto | L 1-3 | Olivares(L,1-2)-M Myers-T Jones | |
| May. 6 | at Toronto | L 1-2 (10) | Thompson-T Jones(L,1-2)-M Myers-Miceli | |
| May. 7 | Kansas City | W 12-3 | Lira(W,1-2)-Bautista-M Myers | Higginson(4);Fryman(7);To Clark(10) |
| May. 8 | Kansas City | L 0-4 | Moehler(L,2-2)-Miceli | |
| May. 9 | Cleveland | L 0-5 | Sager(L,2-2)-Cummings-Miceli-M Myers-Brocail | |
| May. 10 | Cleveland | W 6-0 | Olivares(W,2-2) | To Clark(11);Higginson(5) |
| May. 11 | Cleveland | W 11-3 | Thompson(W,3-2) | To Clark(12,13);Nevin(1);Easley(4) |
| May. 13 | Toronto | W 4-0 | Lira(W,2-2) | Hamelin(1,2) |
| May. 14 | Toronto | L 2-7 | Moehler(L,2-3)-M Myers-T Jones | |
| May. 15 | at Kansas City | L 9-10 | Olivares-Cummings-Miceli-T Jones-Brocail | Nieves(4);To Clark(14) |
| May. 16 | at Kansas City | W 10-2 | Thompson(W,4-2)-Bautista | Nieves(5) |
| May. 17 | at Kansas City | W 9-2 | Pugh(W,1-0)-M Myers | Higginson(6);Brian L Hunter(3);To Clark(15,16) |
| May. 18 | at Kansas City | W 6-5 | Lira-Cummings(W,2-0)-T Jones-M Myers(S,1) | |
| May. 20 | at Baltimore | L 3-4 | Olivares(L,2-3)-Sager | Easley(5) |
| May. 21 | at Baltimore | L 0-2 | Thompson(L,4-3) | |
| May. 23 | Texas | W 7-1 | Moehler(W,3-3)-M Myers | Nieves(6);To Clark(17) |
| May. 24 | Texas | L 4-8 | Pugh(L,1-1)-Bautista-Cummings-Miceli-T Jones-Brocail | |
| May. 25 | Texas | W 13-5 | Lira(W,3-2)-Sager(S,2) | Hamelin(3);Higginson(7) |
| May. 26 | Anaheim | W 6-0 | Olivares(W,3-3) | |
| May. 27 | Anaheim | W 6-2 | Thompson(W,5-3)-T Jones-Brocail-M Myers(S,2) | Fryman(8) |
| May. 28 | Baltimore | L 1-8 | Moehler(L,3-4)-Cummings-Miceli-Brocail-M Myers | |
| May. 29 | Baltimore | Postponed by Rain | ||
| May. 30 | at Seattle | W 5-2 | Lira(W,4-2)-Miceli-M Myers-T Jones(S,4) | |
| May. 31 | at Seattle | W 4-2 | Olivares(W,4-3)-M Myers-Miceli-T Jones(S,5) | |